发给老马备查:
: Q' `- E, I* A$ i/ n滴水察海(69304838) 15:23:23# f* U0 b. \9 u6 ]* O( m; Z
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
F3 @+ E0 b( @- p7 c吉非替尼和S-1连用的依据
7 b, T; n9 j% Z; V% d( y$ yGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.3 m4 ]) R7 M8 |
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
/ \6 Y7 Q( ~, B: s; X这样是不是推理出,耐药后,可以用S-1和培美了?0 n- ~6 P$ p) j
结论:* e: p* R# G& S& _) a9 g
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |