发给老马备查:9 a4 }( V \$ d( a; ^
滴水察海(69304838) 15:23:23/ p/ [# n+ o7 ]% k
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱5 b& a4 F; H; r, x8 O8 R2 v
吉非替尼和S-1连用的依据/ Y& f+ r) p$ d" x) E9 D/ ]
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro., f; h0 m" _' N, E8 m- E% q
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
* y5 d1 t7 O2 ^- x这样是不是推理出,耐药后,可以用S-1和培美了?# o. F& F. ] E
结论:
- S. e4 Z& ~) @) F如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |