发给老马备查:
! N8 a- c! s* j2 Z滴水察海(69304838) 15:23:23
3 S0 s! i4 l( v3 M$ g/ {老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱2 r7 j1 {; D+ m7 W- L* m* z6 H6 n
吉非替尼和S-1连用的依据1 L) ?# c) \, U3 }/ U z
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
7 r6 T: n* ^! b+ @! a6 i( H+ v是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达# J1 V- J2 F: Q4 x5 K, T" f) c! [) J
这样是不是推理出,耐药后,可以用S-1和培美了?; P1 a2 f+ \3 k8 g6 Y, X& a
结论: _! l; f- j7 r! x) N& e
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |