发给老马备查:1 u) a6 W- w, g5 }1 s; T+ z
滴水察海(69304838) 15:23:23
2 ]9 E G0 ^* D- x5 E3 O. O8 M老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
2 M+ W% T9 m6 J# X+ _吉非替尼和S-1连用的依据
# T7 J! j. p; EGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
- M M, L2 f2 f4 ?$ o2 p4 \4 N是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
' y% |* o1 s2 H# L* l) X: B这样是不是推理出,耐药后,可以用S-1和培美了?
8 z1 p+ g& H4 R结论:
2 P# ~, |) W' {# o9 \# ]如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |