发给老马备查:9 ?& ^; a5 ~5 V8 A0 e `$ [
滴水察海(69304838) 15:23:234 G6 |0 |* P9 ?3 ]4 N
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
v. A& [2 O: y" ~吉非替尼和S-1连用的依据
2 R4 A: z/ x+ s8 R1 [, KGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro. S& {7 \5 h1 s/ y3 N4 G
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
) \$ E% g4 W2 s1 J# V, l: I这样是不是推理出,耐药后,可以用S-1和培美了?4 I& t4 Y5 G2 m& D4 F
结论:! k1 b9 N8 Q; x' b
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |